In a large skillet, heat the oil over medium-high heat.
Cook the onion until soft. Add in the ground turkey and seasonings, (cayenne through garlic). Break the turkey up with a wooden spoon while cooking.
Once the mixture is completely cooked through stir in the cilantro, remove from the heat and set aside.
In 4 medium bowls, line the bottom and sides with the lettuce leaves. Scoop in the ground turkey mixture and serve.